منابع مشابه
Synthesis of a ring-expanded bryostatin analogue.
The bryostatins are a family of marine natural products that display a wide range of biological activities, most notably their anticancer activity in vivo.1 This effect is attributed to their ability to modulate the functions of protein kinase C isozymes within cells. One of the members of this family, bryostatin 1, is currently in several phase I and phase II clinical trials for the treatment ...
متن کاملTotal synthesis of sulfolipid-1.
Sulfolipid-1, a tetra-acylated sulfotrehalose from Mycobacterium tuberculosis, was isolated over 40 years ago. Being a main component of the mycomembrane of M. tuberculosis, its biosynthesis and function have been studied in depth, but the chemical synthesis of sulfolipid-1 has not been reported. The synthesis presented here is based on iterative catalytic asymmetric conjugate additions of meth...
متن کاملTotal Synthesis of Taxol . 1
A successful strategy for the enantioselective synthesis of the natural stereoisomer of Taxol (1) has been developed. This strategy utilized the convergent assembly of Taxol's central eight-membered B ring from preformed synthons for rings A (10) and C (9) followed by late introduction of the D ring and side chain. Degradative studies conf i ied the viability of certain crucial manipulations in...
متن کامل1 Total synthesis of a 20 - deoxybryostatin
Chromatography was performed using Merck silica gel (60H; 40-60, 230-240 mesh). Petrol refers to light petroleum which was redistilled before use and refers to the fraction boiling between 40 and 60 °C. Tetrahydrofuran was dried over sodium-benzophenone and was distilled prior to use. Dichloromethane was dried over CaH2 and was distilled before use. Ether refers to diethyl ether. Reactions und...
متن کاملVaried differentiation responses of human leukemias to bryostatin 1.
Bryostatin 1, a macrocyclic lactone isolated from a marine bryozoan, has significant antineoplastic activity against the murine cell line P388. Like phorbol esters, bryostatin 1 is capable of binding to and activating protein kinase C, but these two compounds differ in the ability of bryostatin 1 to act as a tumor promoter. We have investigated whether bryostatin 1 can modulate the differentiat...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of the American Chemical Society
سال: 2011
ISSN: 0002-7863,1520-5126
DOI: 10.1021/ja110198y